• Dipeptidyl peptidase inhibitors DPP is or gliptins stimulate

  2020-07-16

  

  Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit rho kinase inhibitors secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good ef

• One of the critical functions of the

  2020-07-16

  

  One of the critical functions of the product of the AR gene is to activate the expression of target genes. This transactivation activity resides in the N-terminal domain of the protein encoded in exon 1, which contains polymorphic repeats. These trinucleotide repeats, (CAG) and (GGC), encode polyglu

• The nuclear receptor related protein Nurr NR

  2020-07-16

  

  The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the protease activated receptor of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al.,

• herpes simplex virus type 1 Proteins that associate to PCNA

  2020-07-16

  

  Proteins that associate to PCNA are characterized by having conserved motifs as the PCNA-interacting protein (PIP) motif [29,30], its variant PIP-like motif [31,32] or the APIM motif (Alk B homologue 2 PCNA interacting motif [33,34]); for instance, p21 contains a PIP motif [30], and DNA polymerases

• MRS 2365 CK enzymes belong to a conserved family of serine

  2020-07-16

  

  CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, MRS 2365 progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regulate developmental

• Both progesterone and the calcium ionophore A

  2020-07-16

  

  Both progesterone and the calcium ionophore A23187 rely on the synthesis of cAMP by sAC to elicit exocytosis in human sperm (Fig. 2E-H and [8], [60]). We had reported earlier that digestion of endogenous cAMP with recombinant cAMP-specific phosphodiesterase 4D [9] or inhibition of its synthesis with

• It has been reported that

  2020-07-15

  

  It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several mass of cl australia regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importan

• We report here that ESCL protein exhibits a temporal express

  2020-07-15

  

  We report here that ESCL protein exhibits a temporal expression profile that is complementary to that of ESC, including substantially higher levels of expression during larval and adult stages than embryogenesis. We show that ESCL, like ESC, binds directly to E(Z) via its WD repeats and is physicall

• br Transparency document br Main Text

  2020-07-15

  

  Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes

• It is interesting to note

  2020-07-15

  

  It is interesting to note that oligomerization of recombinant DDR1 ECD primarily occurred when the protein was incubated with collagen in solution and to a much lesser extent when collagen was pre-immobilized on a surface as reported in our earlier studies (Agarwal et al., 2007). We believe that pre

• We next examined the effects of substituents around the

  2020-07-15

  

  We next examined the effects of substituents around the carboxylic NVP-LCQ195 sale moiety on CRTH2 binding (Table 4). The carboxylic acid moiety shared by the representative CRTH2 antagonists and is essential for the CRTH2 activity. Germinal dimethylation of the methylene moiety next to the carboxy

• The mechanisms in the central nervous system

  2020-07-15

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the Pyridone 6 are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enhancement of N

• Recent advances in microarray and next generation sequencing

  2020-07-14

  

  Recent advances in microarray [32] and next-generation sequencing [33] based technologies have led to tremendous increases in information about the molecular mechanisms that are responsible for malignant transformation of rare and poorly understood soft tissue sarcomas. However, data interpretation

• The role of activation of xenosensor nuclear receptors such

  2020-07-14

  

  The role of activation of xenosensor nuclear receptors such as PPARα, CAR, and PXR in producing hepatomegaly and liver tumors in rodents has been well-established (Klaunig et al., 2003, Lake, 2009). In the case of PPARα, the increase in liver weight results from increased peroxisomal mass and expans

• In this study we generated mice in which the

  2020-07-14

  

  In this study we generated mice in which the native Bcl6 locus was engineered to produce a form of Bcl6 containing a mutant RD2 domain that disrupts its repressor function. We found that RD2 domain is essential for pre-GC B cell differentiation and clustering into nascent GC within follicles, in par

15225 records 777/1015 page Previous Next First page 上5页 776777778779780 下5页 Last page