• br Conclusion br Competing interests br Authors contribution

  2020-07-28

  

  Conclusion Competing interests Authors\' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number

• In conclusion adipose PGD suppressed the lipolysis by decrea

  2020-07-28

  

  In conclusion, adipose PGD2 suppressed the lipolysis by decreasing the intracellular cAMP level through DP2R. Therefore, PGD2 enhanced adipocyte differentiation (lipid accumulation) through both repression of the lipolysis via DP2R and activation of the lipogenesis via PPARγ. Thus, L-PGDS and DP2R a

• Introduction Piperine is a pungent alkaloid

  2020-07-28

  

  Introduction Piperine is a pungent alkaloid and accounts for 2–5% dry weight in black and white peppers (Butt et al., 2013). Physiological benefits of piperine have been a subject of extensive research in recent years. Piperine is an antioxidant with strong anti-inflammatory and antiangiogenic acti

• Our data raise the question on the criteria

  2020-07-27

  

  Our data raise the question on the criteria of ERα evaluation in the lung, as they exclude a priori the most prevalent ERs (extranuclear variants). As we show here, it is the localization of ERα immunoreactive molecules that makes the hallmark in variation within various cell types and gender, non-t

• mAbs directed against RTKs are invaluable tools for research

  2020-07-27

  

  mAbs directed against RTKs are invaluable tools for research and have been developed into successful therapeutics (Adams and Weiner, 2005). We have characterized seven anti-DDR1 mAbs that inhibit DDR1 function by binding to two distinct regions in the DS-like domain. Notably, Fab fragments derived f

• DNA PK plays an essential role in protecting genome

  2020-07-27

  

  DNA-PK plays an essential role in protecting genome stability during the events of double-strand break (DSB), and considered crucial component in NHEJ repair pathway. Where, in such pathway, DNA-PKcs is recruited at the site of DSB by the Ku protein, which in turn recruits and phosphorylates a nucle

• A small subset of compounds composed the triazino

  2020-07-27

  

  A small subset of compounds composed the 5-[1,2,4]triazino[5,6-]indole cluster (). This series of compounds was characterised by a central heterocyclic core with an R1 alkyl amine chain, required for potency (. , , and ), with preference for morpholine over piperidine (. ). The scaffold can be subst

• histamine-2 receptor antagonist It seems that not only

  2020-07-27

  

  It seems that not only catalytic domains, but also other motifs and the phosphorylation status of LRRK2 are important for its cellular functions [75]. The WD40 domain was shown to mediate interactions of LRRK2 with the microtubules [76]. Recently, Kalogeropulou et al. [77] identified p62 as a novel

• Activation of CDK involves binding of CDKs with their

  2020-07-27

  

  Activation of CDK involves binding of CDKs with their respective cyclins at the C-terminal via noncovalent interactions and leads to the accessibility of ATP to the catalytic site for phosphorylation of threonine. A list depicting the association of cyclins with CDKs and their overexpression in var

• The Ki antibody is reactive with human nuclear

  2020-07-27

  

  The Ki-67 antibody is reactive with human nuclear proteins associated with cell proliferation. Recently, CXCR-4 has been shown to directly or indirectly regulate proliferation of some ovarian and breast cancer cell lines in culture., However, no reports have examined the relationship between CXCR-4

• Chemokines are involved not only in the migration

  2020-07-27

  

  Chemokines are involved not only in the migration of neutrophils but also their prolonged accumulation at the site of inflammation. Chemokine receptors that play a pivotal role in the process of neutrophil accumulation (holding) are not very well defined. Stimulation of neutrophils with LPS and TNF-

• The Ki antibody is reactive with human nuclear

  2020-07-27

  

  The Ki-67 antibody is reactive with human nuclear proteins associated with cell proliferation. Recently, CXCR-4 has been shown to directly or indirectly regulate proliferation of some ovarian and breast cancer cell lines in culture., However, no reports have examined the relationship between CXCR-4

• br Nuclear export and the functions of CRM The nuclear

  2020-07-27

  

  Nuclear export and the functions of CRM1 The nuclear envelope provides a compartmentalized intracellular environment for DNA replication, the synthesis of RNA, and production of ribosomes, and, as such, it can regulate cellular biological processes including apoptosis and proliferation. Nucleocyt

• br Application of the BN Cox

  2020-07-27

  

  Application of the BN-Cox model to risk calculation As we mentioned earlier, CPH models are widely used in medical risk assessment and are often reported in the literature. Recently, we proposed a BN-Cox-based risk score calculator to the existing Pulmonary Arterial Hypertension (PAH) risk calcul

• In this review we present compelling evidence in

  2020-07-25

  

  In this review, we present compelling evidence in support of DHODH as an essential enzyme for the survival of cancer cells. DHODH, and its relationship to de novo pyrimidine metabolism, will be discussed along with factors that influence its regulation and expression. We will show evidence of DHODH\

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